Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GLCTK. AA range:101-150
Specificity
Glycerate Kinase Polyclonal Antibody detects endogenous levels of Glycerate Kinase protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009],
Function
catalytic activity:ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.,disease:Defects in GLYCTK are the cause of D-glyceric acidemia [MIM:220120]. It is characterized by nonketotic hyperglycinemia with the excretion of D-glyceric acid in the urine and the presence of this substance in the serum.,similarity:Belongs to the glycerate kinase type-2 family.,tissue specificity:Widely expressed.,
Protein name
Glycerate kinase
Abbreviation
Glycerate Kinase
Other name
GLYCTK; HBEBP4; LP5910; Glycerate kinase; HBeAg-binding protein 4
Fields
>>Pentose phosphate pathway;>>Glycine, serine and threonine metabolism;>>Glycerolipid metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Metabolic pathways;>>Carbon metabolism
Human protein sequence Database
Q8IVS8
Mouse protein sequence database
Q8QZY2
Rat protein sequence database
Q0VGK3
Cellular localization
[Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm. Mitochondrion .
Tissue expression
Widely expressed.
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