Immunogen
Synthesized acetyl-peptide derived from human RIP140 around the acetylation site of K158.
Specificity
Acetyl-RIP140 (K158) Polyclonal Antibody detects endogenous levels of RIP140 around the acetylation site of K158 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008],
Function
disease:Genetic variation in NRIP1 may act as predisposing factor for endometriosis.,domain:Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.,function:Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.,PTM:Acetylation regulates its nucle
Protein name
Nuclear receptor-interacting protein 1
Other name
NRIP1; Nuclear receptor-interacting protein 1; Nuclear factor RIP140; Receptor-interacting protein 140
Human protein sequence Database
P48552
Mouse protein sequence database
Q8CBD1
Rat protein sequence database
Cellular localization
Nucleus . Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
Tissue expression
Brain,Epithelium,Mammary gland,Skin,
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