Molecular weight (DA)
23kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RAB14 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009],
Function
function:May be involved in vesicular trafficking and neurotransmitter release.,similarity:Belongs to the small GTPase superfamily. Rab family.,
Protein name
Ras-related protein Rab-14
Fields
>>AMPK signaling pathway
Human protein sequence Database
P61106
Mouse protein sequence database
Q91V41
Rat protein sequence database
P61107
Cellular localization
Recycling endosome . Early endosome membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle, phagosome . Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). .
Tissue expression
Adrenal gland,B-cell lymphoma,Brain,Liver,Melanoma,Placenta,Platele
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