Molecular weight (DA)
16kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human GYPA. AA range:41-90
Specificity
CD235a Polyclonal Antibody detects endogenous levels of CD235a protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008],
Function
function:Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virus.,online information:Blood group antigen gene mutation database,polymorphism:Along with GYPB, GYPA is responsible for the MNS blood group system.,similarity:Belongs to the glycophorin A family.,
Protein name
Glycophorin-A
Other name
GYPA; GPA; Glycophorin-A; MN sialoglycoprotein; PAS-2; Sialoglycoprotein alpha; CD235a
Fields
>>Hematopoietic cell lineage;>>Malaria
Human protein sequence Database
P02724
Mouse protein sequence database
P14220
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Appears to be colocalized with SLC4A1.
Tissue expression
Blood,Bone marrow,Kidney,Liver,Lung,Miltenberger class V,
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