Molecular weight (DA)
45kD
Immunogen
Synthesized peptide derived from Blood group Rh(D) polypeptide at AA range: 161-210
Specificity
CD240d Polyclonal Antibody detects endogenous levels of CD240d protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.,online information:Blood group antigen gene mutation database,polymorphism:RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a polymorphism in position 110.,similarity:Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.,tissue specificity:Restricted to tissues or cell lines expressing erythroid characters.,
Protein name
Blood group Rh(D) polypeptide
Other name
RHD; Blood group Rh(D) polypeptide; RHXIII; Rh polypeptide 2; RhPII; Rhesus D antigen; CD240D
Human protein sequence Database
Q02161
Mouse protein sequence database
Q8CF94
Rat protein sequence database
O88298
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Restricted to tissues or cell lines expressing erythroid characters.
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