Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD207. AA range:61-110
Specificity
CD207 Polyclonal Antibody detects endogenous levels of CD207 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010],
Function
function:Calcium-dependent lectin displaying mannose-binding specificity, Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering.,online information:Langerin,similarity:Contains 1 C-type lectin domain.,subcellular location:Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.,tissue specificity:Exclusively expressed by Langerhans cells.,
Protein name
C-type lectin domain family 4 member K
Other name
CD207; CLEC4K; C-type lectin domain family 4 member K; Langerin; CD207
Human protein sequence Database
Q9UJ71
Mouse protein sequence database
Q8VBX4
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type II membrane protein . Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Tissue expression
Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
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