Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD1C. AA range:211-260
Specificity
CD1C Polyclonal Antibody detects endogenous levels of CD1C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008],
Function
function:Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.,miscellaneous:During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subcellular location:Subject to intracellular trafficking between the cell membrane and endosomes.,subunit:Heterodimer with B2M (beta-2-microglobulin).,tissue specificity:Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.,
Protein name
T-cell surface glycoprotein CD1c
Other name
CD1C; T-cell surface glycoprotein CD1c; CD1c
Fields
>>Tight junction;>>Hematopoietic cell lineage;>>Amoebiasis
Human protein sequence Database
P29017
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein. Lysosome . Subject to intracellular trafficking between the cell membrane and endosomes. .
Tissue expression
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
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