Molecular weight (DA)
36kD
Immunogen
Synthetic peptide from human protein at AA range: 101-150
Specificity
CD272 Polyclonal Antibody detects endogenous levels of CD272 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011],
Function
function:Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.,PTM:N-glycosylated.,PTM:Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.,
Protein name
B- and T-lymphocyte attenuator
Other name
BTLA; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD antigen CD272
Human protein sequence Database
Q7Z6A9
Mouse protein sequence database
Q7TSA3
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
PCR rescued clones,Peripheral blood,Thymus,Trachea,
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