Molecular weight (DA)
34kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RNF41 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011],
Function
function:Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, such as ERBB3.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SIAH-type zinc finger.,subunit:Interacts with USP8 and ERBB3.,tissue specificity:Detected in ovary, testis and prostate.,
Gene Name
RNF41 FLRF NRDP1 SBBI03
Protein name
E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41)
Human protein sequence Database
Q9H4P4
Mouse protein sequence database
Q8BH75
Rat protein sequence database
Cellular localization
cytosol,
Tissue expression
Detected in ovary, testis and prostate.
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