Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from MLKL . at AA range: 40-120
Specificity
MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Function
domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
Mixed lineage kinase domain-like protein
Other name
MLKL; Mixed lineage kinase domain-like protein
Fields
>>Necroptosis;>>TNF signaling pathway;>>Salmonella infection
Human protein sequence Database
Q8NB16
Mouse protein sequence database
Q9D2Y4
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
Tissue expression
Chondrocyte,Leukocyte,Lymph node,
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