Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HRH2. AA range:131-180
Specificity
Histamine H2 Receptor Polyclonal Antibody detects endogenous levels of Histamine H2 Receptor protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function
function:The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.,miscellaneous:Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.,online information:H2 receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Histamine H2 receptor
Abbreviation
Histamine H2 Receptor
Other name
HRH2; Histamine H2 receptor; H2R; HH2R; Gastric receptor I
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gastric acid secretion
Human protein sequence Database
P25021
Mouse protein sequence database
P97292
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Brain,Liver,Skin,Stomach,
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