Immunogen
The antiserum was produced against synthesized peptide derived from human GPR143. AA range:151-200
Specificity
GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009],
Function
disease:Defects in GPR143 are the cause of ocular albinism type 1 (OA1) [MIM:300500]; also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity, retinal hypopigmentation and the presence of macromelanosomes.,function:Not known; binds heterotrimeric G proteins.,online information:GPR143 mutations,online information:Retina International's Scientific Newsletter,similarity:Belongs to the G-protein coupled receptor OA family.,subcellular location:Targeted to intracellular organelles, namely the melanosomes in pigment cells.,tissue specificity:Exclusively expressed in pigment cells.,
Protein name
G-protein coupled receptor 143
Other name
GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein
Human protein sequence Database
P51810
Mouse protein sequence database
P70259
Rat protein sequence database
Cellular localization
Melanosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673). .
Tissue expression
Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车