Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR119. AA range:186-235
Specificity
GPR119 Polyclonal Antibody detects endogenous levels of GPR119 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010],
Function
function:Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in the pancreas, especially in the islets.,
Protein name
Glucose-dependent insulinotropic receptor
Other name
GPR119; Glucose-dependent insulinotropic receptor; G-protein coupled receptor 119
Fields
>>cAMP signaling pathway;>>Insulin secretion
Human protein sequence Database
Q8TDV5
Mouse protein sequence database
Q7TQP3
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Predominantly expressed in the pancreas, especially in the islets.
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