Molecular weight (DA)
41kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PRLHR. AA range:184-233
Specificity
GPR10 Polyclonal Antibody detects endogenous levels of GPR10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008],
Function
function:Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.,induction:Repressed by bromocriptine, a dopamine agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.,tissue specificity:Only detected in the pituitary gland and in all cell types of pituitary adenomas.,
Protein name
Prolactin-releasing peptide receptor
Other name
PRLHR; GPR10; GR3; Prolactin-releasing peptide receptor; PrRP receptor; PrRPR; G-protein coupled receptor 10; hGR3
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P49683
Mouse protein sequence database
Q6VMN6
Rat protein sequence database
Q64121
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Only detected in the pituitary gland and in all cell types of pituitary adenomas.
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