Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDKL1. AA range:281-330
Specificity
KKIALRE Polyclonal Antibody detects endogenous levels of KKIALRE protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The [NKR]KIAxRE motif seems to be a cyclin-binding region.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in kidney, and to a lower extent in ovary.,
Protein name
Cyclin-dependent kinase-like 1
Other name
CDKL1; Cyclin-dependent kinase-like 1; Protein kinase p42 KKIALRE; Serine/threonine-protein kinase KKIALRE
Human protein sequence Database
Q00532
Mouse protein sequence database
Q8CEQ0
Rat protein sequence database
Q66HE7
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Highly expressed in kidney, and to a lower extent in ovary.
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