Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FSHR. AA range:211-260
Specificity
FSHR Polyclonal Antibody detects endogenous levels of FSHR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p: 100-300.WB: 1/500 - 1/2000. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Function
disease:Defects in FSHR are a cause of ovarian dysgenesis 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).,disease:Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargeme
Protein name
Follicle-stimulating hormone receptor
Other name
FSHR; LGR1; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Ovarian steroidogenesis
Human protein sequence Database
P23945
Mouse protein sequence database
P35378
Rat protein sequence database
P20395
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Sertoli cells and ovarian granulosa cells.
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