Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human NTS. AA range:121-170
Specificity
Neurotensin Polyclonal Antibody detects endogenous levels of Neurotensin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014],
Function
function:Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.,online information:Neurotensin entry,similarity:Belongs to the neurotensin family.,subcellular location:Packaged within secretory vesicles.,
Protein name
Neurotensin/neuromedin N
Other name
NTS; Neurotensin/neuromedin N
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P30990
Mouse protein sequence database
Q9D3P9
Rat protein sequence database
P20068
Cellular localization
Secreted. Cytoplasmic vesicle, secretory vesicle. Packaged within secretory vesicles.
Tissue expression
Brain,Tongue,
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