Immunogen
The antiserum was produced against synthesized peptide derived from human GnRH I. AA range:43-92
Specificity
GnRH I Polyclonal Antibody detects endogenous levels of GnRH I protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ,IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
gonadotropin releasing hormone 1(GNRH1) Homo sapiens This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015],
Function
function:Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.,online information:Gonadotropin-releasing hormone entry,pharmaceutical:Available under the names Factrel (Ayerst Labs), Lutrepulse or Lutrelef (Ferring Pharmaceuticals) and Relisorm (Serono). Used in evaluating hypothalamic-pituitary gonadotropic function.,similarity:Belongs to the GnRH family.,
Protein name
Progonadoliberin-1
Other name
GNRH1; GNRH; GRH; LHRH; Progonadoliberin-1; Progonadoliberin I
Fields
>>Neuroactive ligand-receptor interaction;>>GnRH signaling pathway;>>GnRH secretion
Human protein sequence Database
P01148
Mouse protein sequence database
P13562
Rat protein sequence database
Cellular localization
Secreted.
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