Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TRHR. AA range:195-244
Specificity
TRH-R1 Polyclonal Antibody detects endogenous levels of TRH-R1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011],
Function
function:Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Thyrotropin-releasing hormone receptor
Other name
TRHR; Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P34981
Mouse protein sequence database
P21761
Rat protein sequence database
Q01717
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Brain,Pituitary,Placenta,
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