Molecular weight (DA)
151kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1110-1190
Specificity
LMTK1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May be involved in neuronal differentiation.,induction:Up-regulated during apoptosis.,PTM:Autophosphorylated. Phosphorylated by CDK5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly perinuclear.,subunit:Interacts with CDK5.,tissue specificity:Expressed in brain.,
Gene Name
AATK AATYK KIAA0641 LMR1 LMTK1
Protein name
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-bi
Human protein sequence Database
Q6ZMQ8
Mouse protein sequence database
Q80YE4
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein . Cytoplasm . Cytoplasm, perinuclear region . Predominantly perinuclear.
Tissue expression
Expressed in brain.
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