Immunogen
The antiserum was produced against synthesized peptide derived from human C5orf13. AA range:13-62
Specificity
P311 Polyclonal Antibody detects endogenous levels of P311 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
P311, also known as C5orf13 (chromosome 5 open reading frame 13), D4S114, PTZ17 or PRO1873, is a 68 amino acid cytoplasmic protein involved in cellular differentiation, neural function and axonal regeneration. Found in the granular layer of the cerebellum, P311 is expressed at lower levels in hippocampus, olfactory bulb, kidney, liver and heart and when expressed ectopically, P311 augments giloma motility. P311 is enriched in mice within the superficial cortical layers and striatum at E20 and the germinal zones at E17. Known to interact with Filamin 1, P311 regulates retinoic-acid lipid-droplet biogenesis, induces myofibroblast ameboid migration and the differentiation of fibroblasts into myofibroblasts. Ser-59 phosphorylation decreases P311 stability; the gene encoding P311 maps to human chromosome 5q22.
Function
regulation of transforming growth factor beta receptor signaling pathway,
Protein name
Neuronal regeneration-related protein
Other name
NREP; C5orf13; P311; Neuronal regeneration-related protein; Neuronal protein 3.1; Protein p311
Human protein sequence Database
Q16612
Mouse protein sequence database
Q07475
Rat protein sequence database
Q80Z34
Cellular localization
Cytoplasm .
Tissue expression
Expressed in lung (at protein level).
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