Immunogen
The antiserum was produced against synthesized peptide derived from human NT-4. AA range:71-120
Specificity
NT-4 Polyclonal Antibody detects endogenous levels of NT-4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008],
Function
function:Target-derived survival factor for peripheral sensory sympathetic neurons.,similarity:Belongs to the NGF-beta family.,tissue specificity:Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.,
Protein name
Neurotrophin-4
Other name
NTF4; NTF5; Neurotrophin-4; NT-4; Neurotrophin-5; NT-5; Neutrophic factor 4
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>PI3K-Akt signaling pathway;>>Neurotrophin signaling pathway
Human protein sequence Database
P34130
Mouse protein sequence database
Q80VU4
Rat protein sequence database
P34131
Cellular localization
Secreted.
Tissue expression
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
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