Molecular weight (DA)
83kD
Immunogen
The antiserum was produced against synthesized peptide derived from human APBB2. AA range:471-520
Specificity
Fe65L Polyclonal Antibody detects endogenous levels of Fe65L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
amyloid beta precursor protein binding family B member 2(APBB2) Homo sapiens The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
Function
function:May modulate the internalization of beta-amyloid precursor protein.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subunit:Binds to the intracellular domain of the beta-amyloid precursor protein.,
Protein name
Amyloid beta A4 precursor protein-binding family B member 2
Other name
APBB2; FE65L; FE65L1; Amyloid beta A4 precursor protein-binding family B member 2; Protein Fe65-like 1
Human protein sequence Database
Q92870
Mouse protein sequence database
Q9DBR4
Rat protein sequence database
Cellular localization
Endoplasmic reticulum . Golgi apparatus . Early endosome .
Tissue expression
Widely expressed.
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