Molecular weight (DA)
116kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ANPRA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (A
Function
catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,function:Receptor for atrial natriuretic peptide. Has guanylate cyclase activity on binding of ANF.,miscellaneous:There seem to be at least three natriuretic peptide hormone receptors: two with guanylate cyclase activity (NPR1/ANP-A and NPR2/ANP-B) and one (NPR3/ANP-C) which is probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction.,PTM:Phosphorylation of the protein kinase-like domain is required for full activation by ANP.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,similarity:Contains 1 protein kinase domain.,
Protein name
Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
Fields
>>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Vascular smooth muscle contraction;>>Thermogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Aldosterone synthesis and secretion
Human protein sequence Database
P16066
Mouse protein sequence database
P18293
Rat protein sequence database
P18910
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Blood,Kidney,Placenta,Retina,
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