Immunogen
Synthetic peptide from human protein at AA range: 371-420
Specificity
The antibody detects endogenous BMP-9
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016],
Function
function:Could be involved in bone formation.,online information:GDF2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Protein name
Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
Other name
Growth/differentiation factor 2 (GDF-2;Bone morphogenetic protein 9;BMP-9)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q9UK05
Mouse protein sequence database
Q9WV56
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Detected in blood plasma (at protein level).
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