Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from human MICB
Specificity
This antibody detects endogenous levels of human MICB
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
Function
disease:Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.,disease:The MICA*004 allele is associated with susceptibility to rheumatoid arthritis [MIM:180300]. Rheumatoid arthritis is a complex, multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction.,function:Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.,induction:By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulate
Other name
MHC class I polypeptide-related sequence B (MIC-B)
Fields
>>Natural killer cell mediated cytotoxicity;>>Kaposi sarcoma-associated herpesvirus infection
Human protein sequence Database
Q29980
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. .
Tissue expression
Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
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