Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL31. AA range:21-70
Specificity
The antibody detects endogenous IL-31
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008],
Function
function:Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.,induction:Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).,tissue specificity:Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.,
Protein name
Interleukin-31 (IL-31)
Other name
Interleukin-31 (IL-31)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q6EBC2
Mouse protein sequence database
Q6EAL8
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
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