Molecular weight (DA)
75+50kD
Immunogen
Synthetic peptide from human protein at AA range: 1-50
Specificity
The antibody detects endogenous TMPO protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by TMPO (thymopoietin) resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in TMPO are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for TMPO.
Function
regulation of transcription,
Protein name
thymopoietin
Human protein sequence Database
P42166/P42167
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus. Chromosome. Expressed diffusely throughout the nucleus.
Tissue expression
Expressed in many tissues. Most abundant in adult thymus and fetal liver.
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