Molecular weight (DA)
66kD
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELE. AA range:100-150
Specificity
E-Selectin Polyclonal Antibody detects endogenous levels of E-Selectin
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008],
Function
function:Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.,online information:E-selectin,polymorphism:A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).,similarity:Belongs to the selectin/LECAM family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 6 Sushi (CCP/SCR) domains.,subunit:Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.,
Fields
>>Cell adhesion molecules;>>TNF signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P16581
Mouse protein sequence database
Q00690
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein.
Tissue expression
Umbilical vein endothelial cell,
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