Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RAMP2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008],
Function
function:Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.,similarity:Belongs to the RAMP family.,subunit:Heterodimer of CALCRL and RAMP2.,tissue specificity:Strongly expressed in lung, breast, immune system and fetal tissues.,
Protein name
Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)
Fields
>>Vascular smooth muscle contraction
Human protein sequence Database
O60895
Mouse protein sequence database
Q9WUP0
Rat protein sequence database
Q9JHJ1
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Strongly expressed in lung, breast, immune system and fetal tissues.
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