Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RTCD1. AA range:317-366
Specificity
RTCD1 Polyclonal Antibody detects endogenous levels of RTCD1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RNA 3'-terminal phosphate cyclase(RTCA) Homo sapiens This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012],
Function
catalytic activity:ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate.,function:Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.,similarity:Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.,subunit:Monomer.,tissue specificity:Ubiquitous.,
Protein name
RNA 3'-terminal phosphate cyclase
Other name
RTCA; RPC; RPC1; RTC1; RTCD1; RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA-3'-phosphate cyclase; RNA terminal phosphate cyclase domain-containing protein 1; RTC domain-containing protein 1
Human protein sequence Database
O00442
Mouse protein sequence database
Q9D7H3
Rat protein sequence database
Cellular localization
Nucleus, nucleoplasm .
Tissue expression
Ubiquitous.
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