Molecular weight (DA)
98kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DSC3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],
Function
domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.,similarity:Contains 5 cadherin domains.,tissue specificity:Epidermis, buccal mucosa, esophagus and cervix.,
Gene Name
DSC3 CDHF3 DSC4
Protein name
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Human protein sequence Database
Q14574
Mouse protein sequence database
P55850
Rat protein sequence database
Cellular localization
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Tissue expression
Epidermis, buccal mucosa, esophagus and cervix.
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