Molecular weight (DA)
179kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SCRIB Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Function
similarity:Contains 4 PDZ (DHR) domains.,
Gene Name
SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL
Protein name
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Fields
>>Hippo signaling pathway;>>Tight junction;>>Human papillomavirus infection;>>Viral carcinogenesis
Human protein sequence Database
Q14160
Mouse protein sequence database
Q80U72
Rat protein sequence database
Cellular localization
Cell membrane ; Peripheral membrane protein. Cell junction . Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). .
Tissue expression
Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
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