Molecular weight (DA)
68kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 353-403
Specificity
RBP10 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RAN binding protein 10(RANBP10) Homo sapiens RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
Function
domain:The SPRY domain mediates the interaction with MET.,function:May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.,similarity:Belongs to the RANBP9/10 family.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 CTLH domain.,similarity:Contains 1 LisH domain.,subunit:Interacts with RAN. Interacts with the HGF receptor MET.,tissue specificity:Broadly expressed, with highest levels in skeletal muscle.,
Gene Name
RANBP10 KIAA1464
Protein name
Ran-binding protein 10 (RanBP10)
Human protein sequence Database
Q6VN20
Mouse protein sequence database
Q6VN19
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Nucleus . Predominantly cytoplasmic.
Tissue expression
Broadly expressed, with highest levels in skeletal muscle.
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