Molecular weight (DA)
63kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 128-178
Specificity
KLC1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-
Function
alternative products:Additional isoforms seem to exist. Has the potential to produce 285'919 splice forms,caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.,miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.,PTM:Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.,similarity:Belongs to the kinesin light chain family.,similarity:Contains 6 TPR repeats.,subunit:Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9.,tissue specificity:Found in a variety of tissues. Mostly abundant in brain and spine.,
Protein name
Kinesin light chain 1 (KLC 1)
Fields
>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection
Human protein sequence Database
Q07866
Mouse protein sequence database
O88447
Rat protein sequence database
P37285
Cellular localization
Cell projection, growth cone . Cytoplasmic vesicle . Cytoplasm, cytoskeleton .
Tissue expression
Found in a variety of tissues. Mostly abundant in brain and spine.
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