Molecular weight (DA)
86kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 302-352
Specificity
CASS4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
alternative products:Experimental confirmation may be lacking for some isoforms,function:Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK activity, focal adhesion integrity, and cell spreading.,PTM:Phosphorylated on tyrosines by SRC.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,subunit:Interacts (via SH3 domain) with focal adhesion kinase (via C-terminus).,tissue specificity:Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines.,
Function
alternative products:Experimental confirmation may be lacking for some isoforms,function:Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK activity, focal adhesion integrity, and cell spreading.,PTM:Phosphorylated on tyrosines by SRC.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,subunit:Interacts (via SH3 domain) with focal adhesion kinase (via C-terminus).,tissue specificity:Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines.,
Gene Name
CASS4 C20orf32 HEFL
Protein name
Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL)
Human protein sequence Database
Q9NQ75
Mouse protein sequence database
Q08EC4
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Cell junction, focal adhesion .
Tissue expression
Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines.
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