Molecular weight (DA)
51kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
PACR Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010],
Function
function:This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.,
Protein name
Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Circadian entrainment;>>Insulin secretion;>>Renin secretion
Human protein sequence Database
P41586
Mouse protein sequence database
P70205
Rat protein sequence database
P32215
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
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