Molecular weight (DA)
41kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRPS22. AA range:231-280
Specificity
MRP-S22 Polyclonal Antibody detects endogenous levels of MRP-S22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene
Function
disease:Defects in MRPS22 are the cause of combined oxidative phosphorylation deficiency type 5 (COXPD5) [MIM:611719]. COXPD5 is an antenatal mitochondrial disease. Patients show edema, cardiomyopathy, tubulopathy, and hypotonia.,subunit:Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.,
Protein name
28S ribosomal protein S22 mitochondrial
Other name
MRPS22; C3orf5; RPMS22; GK002; 28S ribosomal protein S22; mitochondrial; MRP-S22; S22mt
Human protein sequence Database
P82650
Mouse protein sequence database
Q9CXW2
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Brain,Liver cancer,Muscle,Placenta,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车