Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
CALRL Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,subunit:Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.,tissue specificity:Predominantly expressed in the lung and heart.,
Function
function:Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,subunit:Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.,tissue specificity:Predominantly expressed in the lung and heart.,
Protein name
Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)
Fields
>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction
Human protein sequence Database
Q16602
Mouse protein sequence database
Q9R1W5
Rat protein sequence database
Q63118
Cellular localization
Cell membrane ; Multi-pass membrane protein.
Tissue expression
Predominantly expressed in the lung and heart.
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