Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 110-190
Specificity
PGS1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015],
Function
function:May be involved in collagen fiber assembly.,PTM:The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,subunit:Homodimer. Forms a ternary complex with MFAP2 and ELN.,tissue specificity:Found in several connective tissues, especially in articular cartilages.,
Protein name
Biglycan (Bone/cartilage proteoglycan I) (PG-S1)
Human protein sequence Database
P21810
Mouse protein sequence database
P28653
Rat protein sequence database
P47853
Cellular localization
Secreted, extracellular space, extracellular matrix .
Tissue expression
Found in several connective tissues, especially in articular cartilages.
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