Molecular weight (DA)
113kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 430-510
Specificity
SEM6A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011],
Function
function:Can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 PSI domain.,similarity:Contains 1 Sema domain.,subunit:Active as a homodimer or oligomer. Interacts with EVL.,
Gene Name
SEMA6A KIAA1368 SEMAQ
Protein name
Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)
Human protein sequence Database
Q9H2E6
Mouse protein sequence database
O35464
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Brain,Hypothalamus,Placenta,
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