Molecular weight (DA)
122kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 630-710
Specificity
BOC Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014],
Function
function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.,miscellaneous:The C-terminal cytoplasmic domain is not required for the stimuation of myogenesis.,PTM:N-glycosylated.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Enriched at sites of cell-cell contact.,subunit:Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.,tissue specificity:Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.,
Gene Name
BOC UNQ604/PRO1190
Protein name
Brother of CDO (Protein BOC)
Fields
>>Hedgehog signaling pathway;>>Axon guidance
Human protein sequence Database
Q9BWV1
Mouse protein sequence database
Q6AZB0
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Enriched at sites of cell-cell contact.
Tissue expression
Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.
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