Molecular weight (DA)
120kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MYBPC1. AA range:218-267
Specificity
MYBPC1 Polyclonal Antibody detects endogenous levels of MYBPC1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
Function
function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.,similarity:Belongs to the immunoglobulin superfamily. MyBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,
Protein name
Myosin-binding protein C slow-type
Other name
MYBPC1; MYBPCS; Myosin-binding protein C; slow-type; Slow MyBP-C; C-protein, skeletal muscle slow isoform
Human protein sequence Database
Q00872
Mouse protein sequence database
Rat protein sequence database
Q63518
Cellular localization
cytosol,myofibril,myosin filament,
Tissue expression
Brain,Fetal skeletal muscle,Hippocampus,Liver,Muscle pool- 2 tissue
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