Molecular weight (DA)
198kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PAR14 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016],
Function
catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 WWE domain.,similarity:Contains 3 Macro domains.,subcellular location:In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm.,subunit:Interacts with STAT6.,
Gene Name
PARP14 BAL2 KIAA1268
Protein name
Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2)
Human protein sequence Database
Q460N5
Mouse protein sequence database
Q2EMV9
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . In steady state splenocytes the protein is mostly nuclear (By similarity). A minor proportion is detected in the cytoplasm (By similarity). In macrophages, mainly localizes to the cytoplasm (PubMed:27796300). .
Tissue expression
Expressed in macrophages.
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