Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human UTP14A. AA range:321-370
Specificity
UTP14A Polyclonal Antibody detects endogenous levels of UTP14A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
Function
function:May be required for ribosome biogenesis.,miscellaneous:The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the UTP14 family.,tissue specificity:Ubiquitously expressed.,
Protein name
U3 small nucleolar RNA-associated protein 14 homolog A
Other name
UTP14A; SDCCAG16; U3 small nucleolar RNA-associated protein 14 homolog A; Antigen NY-CO-16; Serologically defined colon cancer antigen 16
Fields
>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
Q9BVJ6
Mouse protein sequence database
Q640M1
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Ubiquitously expressed.
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