Molecular weight (DA)
32kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SFRS2B. AA range:31-80
Specificity
SRp46 Polyclonal Antibody detects endogenous levels of SRp46 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
Function
function:Invovlved in pre-mRNA alternative splicing.,PTM:Phosphorylated.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus.,
Protein name
Serine/arginine-rich splicing factor 8
Other name
SRSF8; SFRS2B; SRP46; Serine/arginine-rich splicing factor 8; Pre-mRNA-splicing factor SRP46; Splicing factor SRp46; Splicing factor; arginine/serine-rich 2B
Fields
>>Spliceosome;>>Herpes simplex virus 1 infection
Human protein sequence Database
Q9BRL6
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus.
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