Molecular weight (DA)
12kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 61-110
Specificity
MSMB Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008],
Function
caution:Was originally thought to inhibit the secretion of FSH by pituitary cells.,disease:A genetic variation in MSMB is associated with susceptibility to hereditary prostate cancer type 13 (HPC13) [MIM:611928].,miscellaneous:Specific receptors for this protein are found on spermatozoa and in the prostate.,similarity:Belongs to the beta-microseminoprotein family.,subcellular location:Sperm surface.,subunit:Interacts with PI16.,tissue specificity:Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.,
Protein name
Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-in
Human protein sequence Database
P08118
Mouse protein sequence database
O08540
Rat protein sequence database
P97580
Cellular localization
Secreted. Sperm surface.
Tissue expression
Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.
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