Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
CO8A1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011],
Function
function:Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells.,miscellaneous:Four consecutive Gly-Pro-Pro triplets are present at the C-terminus of the triple-helical region. These may provide the high thermal stability of this region.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Contains 1 C1q domain.,subunit:May form homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens.,
Protein name
Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]
Fields
>>Protein digestion and absorption
Human protein sequence Database
P27658
Mouse protein sequence database
Q00780
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue expression
Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.
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