Molecular weight (DA)
159kD
Immunogen
Synthesized peptide derived from part region of human protein. AA range 21-61
Specificity
PTPRM Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcrip
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 4 fibronectin type-III domains.,
Protein name
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
Fields
>>Cell adhesion molecules;>>Adherens junction
Human protein sequence Database
P28827
Mouse protein sequence database
P28828
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein. Localizes in regions of cell-cell contact. .
Tissue expression
Brain,Clones donated by RIKEN,Plasma,Testis,
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