Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LBP. AA range:221-270
Specificity
LBP Polyclonal Antibody detects endogenous levels of LBP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
lipopolysaccharide binding protein(LBP) Homo sapiens The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012],
Function
function:Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor.,similarity:Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.,
Protein name
Lipopolysaccharide-binding protein
Other name
LBP; Lipopolysaccharide-binding protein; LBP
Fields
>>NF-kappa B signaling pathway;>>Toll-like receptor signaling pathway;>>Alcoholic liver disease;>>Tuberculosis;>>Lipid and atherosclerosis
Human protein sequence Database
P18428
Mouse protein sequence database
Q61805
Rat protein sequence database
Q63313
Cellular localization
Secreted . Cytoplasmic granule membrane . Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. .
Tissue expression
Detected in blood serum (at protein level).
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